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Drug slows Alzheimer's effects

©Associated Press

April 3, 2003

A drug long used in Germany slows down memory loss and physical decline in advanced Alzheimer's patients, according to a study of what could be the first effective treatment for late stages of the mind-robbing ailment.

There is no cure or known prevention for Alzheimer's, which affects about 4-million Americans, and the only medications are approved for earlier stages of the disease.

But a six-month test of the drug memantine in patients with moderate-to-severe Alzheimer's showed it slowed deterioration from the disease, researchers report in today's New England Journal of Medicine.

"It's a breath of fresh air for caregivers and for patients," said Dr. Barry Reisberg of New York University School of Medicine, who led the study.

A second study of memantine used with one of the current Alzheimer's drugs suggests the combination improves memory and thinking skills in advanced patients. That study is being presented today at the American Academy of Neurology's annual meeting.

Memantine is not yet available in the United States, where government review is under way. It was approved for advanced Alzheimer's last year in Europe, where it has been available in Germany for two decades to treat dementia. Alzheimer's is a common form of dementia.

Reisberg's study was paid for by the German drugmaker Merz Pharmaceuticals, whose employees were among the researchers. The second study was funded by Forest Laboratories Inc., which has U.S. marketing rights.

Memantine works differently than approved Alzheimer's drugs by blocking excess amounts of a brain chemical, glutamate, which can lead to nerve cell damage. The most commonly used Alzheimer's drugs -- Aricept, Exelon and Reminyl -- prevent the breakdown of another brain chemical.

In the study by Reisberg's team, 252 patients were given either memantine or a dummy pill for six months and tests to measure their mental and physical abilities.

Both groups saw declines, but the group taking memantine declined by about half as much, Reisberg said. The findings also showed the burden on caregivers was reduced in the memantine group. Side effects were mostly mild, the researchers said.

In the combination study, the 403 patients were already taking one of the Alzheimer's drugs, Aricept. They were given either memantine or a dummy pill for six months.

The patients who got memantine showed a significant improvement in their memory and thinking, said researcher Martin R. Farlow of Indiana University School of Medicine.

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