St. Petersburg Times
 tampabaycom
tampabay.com

Print storySubscribe to the Times

Health

Americans remain world's most medicated people

U.S. prescriptions have swelled by two-thirds over the past decade to 3.5-billion yearly.

By Associated Press
Published April 17, 2005

PLYMOUTH, Mass. - Alice and Ken Heckman each begin their morning by cracking open a rattling plastic tray carting scores of pills in a rainbow of pastel colors.

Between the two of them, they gulp 29 pills every day: a regimen of 14 drugs, with a chaser of dietary supplements.

Here's the curious part: They feel pretty hale for people in their early 70s, working around the house and volunteering with several community groups. They each had heart fixes years ago - him a bypass and her a vessel-clearing stent - but fully recovered. She has well-controlled diabetes. He has worked his way through heartburn, arthritis, an enlarged prostate and occasional depression.

About 130-million Americans - many far healthier than the Heckmans - swallow, inject, inhale, infuse, spray and pat on prescribed medication every month, the U.S. Centers for Disease Control and Prevention indicates. Americans buy much more medicine per person than any other country.

The number of prescriptions has risen by two-thirds over the past decade to 3.5-billion yearly, according to IMS Health, a pharmaceutical consulting company. Americans devour even more nonprescription drugs, polling suggests.

Recently, safety questions have beset some depression and anti-inflammatory drugs, pushing pain relievers Vioxx and Bextra from the market. Rising ranks of doctors, researchers and public health experts are saying that America is overmedicating itself. It is buying and taking far too much medicine, too readily and carelessly, for its own health and wealth, they say.

More than 125,000 Americans die from drug reactions and mistakes each year, according to Associated Press projections from landmark medical studies of the 1990s. That could make pharmaceuticals the fourth-leading national cause of death after heart disease, cancer and stroke.

The pharmaceutical industry served up more than $250-billion worth of sales last year, the vast majority in prescriptions, according to industry consultants. That roughly equaled sales at all the country's gasoline stations put together, or an $850 pharmaceutical fillup for every American.

Do we need all these drugs? A relative handful yank many people away from almost certain death, like some antibiotics and AIDS medicines. Though carrying some risk, other drugs - such as cholesterol-cutting statins - help a considerable minority dodge potential calamities like heart attack or stroke.

The right balance of risk and benefit is still harder to strike for a raft of heavily promoted drugs that treat common, persistent, daily life conditions: anti-inflammatories, antacids and pills for allergy, depression, shyness, premenstrual crankiness, waning sexual powers, impulsiveness in children - you name it.

"We are taking way too many drugs for dubious or exaggerated ailments," said Dr. Marcia Angell, former editor of the New England Journal of Medicine and author of The Truth About the Drug Companies. "What the drug companies are doing now is promoting drugs for long-term use to essentially healthy people. Why? Because it's the biggest market."

Relatively few pharmaceutical newcomers greatly improve the health of patients over older drugs or advance the march of medicine. Last year, the U.S. Food and Drug Administration classified about three-quarters of newly approved drugs as similar to existing ones.

Confronted with mounting costs, drugmakers churn out and promote uninspired sequels like Hollywood: drugs with the same ingredients in a different form for a different disease.

Of course, many pharmaceuticals improve American health. "We now have more medicines and better medicines for more diseases," says Jeff Trewhitt of the Pharmaceutical Research and Manufacturers of America.

However, the nation also overindulges far too often, critics say, and violates the classic proscription of the ancient Greek physician Hippocrates: "First, do no harm."

Drug safety researcher Dr. James Kaye of Boston University said he remembers a medical school teacher telling the class: "All drugs are poisonous!"

The Heckmans found out on their own. Heckman lost his alertness for several months to a depression medication. His wife has come down with a rash from one heart medicine and muscle aches from a statin. But each time they switched medicines and escaped any lingering harm.

Hospital patients suffer seven hard-to-foresee adverse drug reactions and another three outright drug mistakes for every 100 admissions, estimates Dr. David Bates, a researcher at Boston's Brigham and Women's Hospital. That translates into 3.6-million drug misadventures a year.

The dangers potentially escalate when doctors prescribe drugs, as they often do, for uses not formally approved by the FDA. In a recent report, the Centers for Disease Control voiced concern about huge off-label growth of antidepressants. They have expanded to treat often loosely defined syndromes of compulsion, panic or anxiety and PMS.

Drugmakers, doctors and patients all have been quick to medicate some conditions once accepted as part of life.

Many Americans also assume, often with a nod from sellers or doctors, that new drugs inevitably work better than old ones. "Newer isn't always better, and more isn't always better," said Dr. Donald Berwick, an adviser to the U.S. Agency for Healthcare Research and Quality.

Around the country, prescription drug sales have pushed relentlessly upward by an annual average of 11 percent over the past five years.

Exercise and better diet ward off heart disease and diabetes just as effectively as drugs do, studies show. However, says Fred Eckel, who teaches pharmacy practice at the University of North Carolina, "There tends to be a reliance on drugs as the first option."

For its part, the FDA generally demands only that new drugs work - not that they work better than existing ones. Dr. Janet Woodcock, an FDA deputy commissioner, says off-label prescribing and allowing similar drugs for the same condition present more options - and "choice is important."

Many safety experts say more new drugs should be tested against marketed ones, with more safety data required.

For now, though, most Americans seem to feel like Heckman: "grateful that there's a pill to take for something."

[Last modified April 17, 2005, 00:26:13]


World and national headlines

  • Excitement builds for secret vote
  • Fugitive, scams pop up in S.C.
  • Indiana: Time for consistent clocks
  • Italian scientists clone horse
  • Rudolph's 'manifesto' is arrogant, unoriginal, experts say
  • Ohio school officials accused of coverup in sexual assault of girl
  • New Attorney General Gonzales' style departs from predecessor's
  • Cambodians observe 30 years of suffering
  • Yellowstone plans policy changes after bear deaths
  • Rudolph to be sent to Rockies' Alcatraz?
  • College, student at odds over tests on Web site
  • Deadly virus forces Angolans to stop saying hello with a hug

  • Achievement Gap
  • Scholastic stars stare down a stigma
  • The invisible men

  • Canada report
  • Conservatives ponder overthrow

  • Health
  • Americans remain world's most medicated people

  • Iraq
  • Sunni militants take close to 100 hostages
  • Women's rights a divisive debate - among women

  • Nation in brief
  • Mild quake hits Southern California
  • Amtrak able to resume partial service on Acela line

  • Terri Schiavo: a long, public death
  • Dean: Democrats plan to use Schiavo case against GOP

  • World in brief
  • G-7 summit tackles oil cost
  • Back to Top

    © 2006 • All Rights Reserved • Tampa Bay Times
    490 First Avenue South • St. Petersburg, FL 33701 • 727-893-8111