tampabay.com

Things looking up for heart patients

By ASSOCIATED PRESS
Published May 2, 2007


CHICAGO - In just six years, death rates and heart failure in hospitalized heart attack patients have fallen sharply, most likely because of better treatment, the largest international study of its kind suggests.

The promising trend parallels the growing use of cholesterol-lowering drugs, powerful blood thinners and angioplasty, the procedure that opens clogged arteries, the researchers said.

"These results are really dramatic, because, in fact, they're the first time anybody has demonstrated a reduction in the development of new heart failure, " said lead author Keith Fox, a cardiology professor at the University of Edinburgh.

The six-year study involved nearly 45, 000 patients in 14 countries who had major heart attacks or dangerous partial artery blockages. The percentage of patients who died in the hospital or who developed heart failure was nearly cut in half from 1999 to 2005.

And the heart attack patients treated most recently were far less likely to have another attack within six months of being hospitalized when compared to the patients treated six years earlier - a sign that the more aggressive efforts of doctors in the last few years are working.

There have been other signs that better treatment of heart patients has been saving lives, but not on a scale as large as this international study, the researchers said. "It's much more dramatic than we expected, in the course of six years, " Fox said.

Patients for the study enrolled between July 1999 through December 2005 and were followed for up to six months after hospitalization. Besides the United States, they were in hospitals in Argentina, Australia, Austria, Belgium, Brazil, Canada, France, Germany, Italy, New Zealand, Poland, Spain and the United Kingdom.

The research showed that in 2005, 4.6 percent of the heart attack patients died in the hospital, compared with 8.4 percent in 1999. Heart failure developed in 11 percent of heart attack patients in 2005, versus nearly 20 percent in 1999. And just 2 percent had subsequent heart attacks in 2005, compared to 4.8 percent previously.

The study appears in today's Journal of the American Medical Association. It was funded by a grant from Sanofi-Aventis, maker of several heart drugs including Plavix and ACE inhibitors. Fox and several other authors reported getting fees and grants from drug makers.