Poor smell recognition possible early Alzheimer's clue

The five-year study of 600 seniors involved identifying common fruit and spice smells.

By ASSOCIATED PRESS
Published July 3, 2007

CHICAGO - Difficulty identifying common smells such as lemon, banana and cinnamon may be the first sign of Alzheimer's disease, according to a study that could lead to scratch-and-sniff tests to determine a person's risk for the progressive brain disorder.

Such tests could be important if scientists find ways to slow or stop Alzheimer's and the severe memory loss associated with it. For now, there's no cure for the more than 5-million Americans with the disease.

Researchers have long known that microscopic lesions considered the hallmarks of Alzheimer's first appear in a brain region important to the sense of smell.

"Strictly on the basis of anatomy, yeah, this makes sense, " said Robert Franks, an expert on odor perception and the brain at the University of Cincinnati. Franks was not involved in the new study, appearing in Monday's Archives of General Psychiatry.

In the study, 600 people between the ages of 54 and 100 were asked to identify 12 familiar smells: onion, lemon, cinnamon, black pepper, chocolate, rose, banana, pineapple, soap, paint thinner, gasoline and smoke.

A quarter of the people correctly identified all the odors or missed only one. Half of them knew at least nine of the 12. The lowest-scoring quarter of the people correctly identified eight or fewer of the odors.

The subjects took 21 cognitive tests annually over the next five years. About one-third of the people developed at least mild trouble with memory and thinking.

The people who made at least four errors on the odor test were 50 percent more likely to develop problems than people who made no more than one error. Difficulty identifying odors also was associated with a higher risk of progressing from mild cognitive impairment to Alzheimer's.

Lead author Robert Wilson of Chicago's Rush University Medical Center said a diminishing sense of smell isn't cause for panic. "Not all low scorers went on to have cognitive problems, " he said.

[Last modified July 2, 2007, 22:25:37]